BDBM50399415 CHEMBL2178872

SMILES FC(F)(F)CCc1cc(on1)-c1cncc(OC[C@@H]2CCN2)c1

InChI Key InChIKey=PUCADISPXQCOJH-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50399415   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50399415(CHEMBL2178872)
Affinity DataEC50:  53.7nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in human SH-EP1 cells assessed as stimulation of 86Rb+ efflux preincubated for 10 mins by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50399415(CHEMBL2178872)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in human SH-EP1 cells assessed as stimulation of 86Rb+ efflux preincubated for 10 mins by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50399415(CHEMBL2178872)
Affinity DataIC50: 83nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in human SH-EP1 cells assessed as inhibition of 86Rb+ efflux preincubated for 10 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50399415(CHEMBL2178872)
Affinity DataIC50: 83.2nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in human SH-EP1 cells assessed as inhibition of 86Rb+ efflux preincubated for 10 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed