BDBM50399458 CHEMBL2179806

SMILES CC(C)(C)c1ccc(CNC(=O)c2cccc(c2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1

InChI Key InChIKey=SJJNZHHGZMUFIM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50399458   

TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399458(CHEMBL2179806)
Affinity DataIC50: 10nMAssay Description:Covalent inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399458(CHEMBL2179806)
Affinity DataIC50: 10nMAssay Description:Covalent inhibition of ITK in presence of 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399458(CHEMBL2179806)
Affinity DataIC50: 12nMAssay Description:Inhibition of BTK in presence of 50 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399458(CHEMBL2179806)
Affinity DataIC50: 516nMAssay Description:Covalent inhibition of ITK in human Jurkat cells assessed as inhibition of anti-CD3 antibody-stimulated PLCgamma phosphorylation pre-incubated before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399458(CHEMBL2179806)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399458(CHEMBL2179806)
Affinity DataIC50: 6.73E+3nMAssay Description:Covalent inhibition of ITK in human whole blood assessed as inhibition of anti-CD3 antibody-stimulated IL2 production pre-incubated before anti-CD3 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed