BDBM50399463 CHEMBL2179816

SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)-c2nn([C@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1

InChI Key InChIKey=GLJLGEAWRQBSGD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50399463   

TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399463(CHEMBL2179816)
Affinity DataIC50: 400nMAssay Description:Covalent inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399463(CHEMBL2179816)
Affinity DataIC50: 780nMAssay Description:Covalent inhibition of ITK in human whole blood assessed as inhibition of anti-CD3 antibody-stimulated IL2 production pre-incubated before anti-CD3 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399463(CHEMBL2179816)
Affinity DataIC50: 1.35E+3nMAssay Description:Covalent inhibition of ITK in human Jurkat cells assessed as inhibition of anti-CD3 antibody-stimulated PLCgamma phosphorylation pre-incubated before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed