BDBM50400180 2,3‐dihydroxy‐6‐[(4‐ isopropylphenyl)sulfanyl]anthracene‐9,10‐dione (Ligand 6)::CHEMBL2180320
SMILES CC(C)c1ccc(Sc2ccc3C(=O)c4cc(O)c(O)cc4C(=O)c3c2)cc1
InChI Key InChIKey=LMCZCWWAGOARCM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50400180
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology
Curated by ChEMBL
Dalian University of Technology
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Binding affinity to Mcl-1 after 30 mins by florescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Binding affinity to Bcl-2 after 30 mins by florescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [172-327](Human)
Dalian University of Technology
Dalian University of Technology
Affinity DataKd: 238nMpH: 8.0 T: 25°CAssay Description:ITC experiments were carried out using iTC200 (Microcal LLC, Northampton, MA, USA) with each of the compounds 1-6 and Mcl-1 protein. The heat of rea...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 50400180
CellInduced myeloid leukemia cell differentiation protein Mcl-1 (aa 172-327)(Human)
Dalian University of Technology
Dalian University of Technology
ITC DataΔG°: -9.08kcal/mole −TΔS°: -4.80kcal/mole ΔH°: -4.25kcal/mole logk: 4.55E+6
pH: 8.0 T: 25.00°C
pH: 8.0 T: 25.00°C