BDBM50400614 CHEMBL2203426

SMILES CCN1CCC(CC1)c1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1

InChI Key InChIKey=FVXFEJBGHYVGML-UHFFFAOYSA-N

Data  1 IC50  2 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50400614   

TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
TBA

Curated by ChEMBL

LigandBDBM50400614(CHEMBL2203426)Copy SMILESCopy InChI

Affinity DataIC50:  37nMAssay Description:Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
TBA

Curated by ChEMBL

LigandBDBM50400614(CHEMBL2203426)Copy SMILESCopy InChI

Affinity DataKd:  1.5nMAssay Description:Binding affinity to FLT3 expressed in HEK-293 cells after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetMacrophage colony-stimulating factor 1 receptor(Human)
TBA

Curated by ChEMBL

LigandBDBM50400614(CHEMBL2203426)Copy SMILESCopy InChI

Affinity DataKd:  3.10nMAssay Description:Binding affinity to CSF1R expressed in HEK-293 cells after 1 hrMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL