BDBM50400705 CHEMBL2204253

SMILES O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3ccc(OC4CCC4)nc3)CC2)C1

InChI Key InChIKey=OUYAIIRDPFHAEM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50400705   

TargetC-C chemokine receptor type 2(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400705BDBM50400705(CHEMBL2204253)
Affinity DataIC50: 27nMAssay Description:Displacement of [125I]-MCP-1 from CCR2 in human THP-1 cells after 2 hrs by microplate scintillation and luminescence counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400705BDBM50400705(CHEMBL2204253)
Affinity DataIC50: 43nMAssay Description:Antagonist activity against CCR2 in human THP-1 cells assessed as inhibition of MCP-1 induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50400705BDBM50400705(CHEMBL2204253)
Affinity DataIC50: 9.80E+3nMAssay Description:Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed