BDBM50401006 CHEMBL2206289

SMILES c1cnc(OC[C@H]2C[C@H](c3ccc(CN4CCCC4)cc3)C2)nc1

InChI Key InChIKey=GRHRNWSXMRDJHN-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50401006   

TargetHistamine H3 receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401006BDBM50401006(CHEMBL2206289)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]-n-alpha-methylhistamine from human histamine H3 receptor homogenate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401006BDBM50401006(CHEMBL2206289)
Affinity DataKi:  8.71nMAssay Description:Displacement of [3H]-n-alpha-methylhistamine from human histamine H3 receptor homogenate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401006BDBM50401006(CHEMBL2206289)
Affinity DataKi:  11.8nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP release pretreate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401006BDBM50401006(CHEMBL2206289)
Affinity DataKi:  12nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP release pretreate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401006BDBM50401006(CHEMBL2206289)
Affinity DataKi:  79nMAssay Description:Antagonist activity at rat histamine H3 receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP release pretreated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401006BDBM50401006(CHEMBL2206289)
Affinity DataKi:  82nMAssay Description:Displacement of [3H]-n-alpha-methylhistamine from rat histamine H3 receptor homogenate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed