BDBM50401768 CHEMBL2207560

SMILES O=C(NC1(CC1)C#N)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1

InChI Key InChIKey=CJTVJJOGOYUWJE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50401768   

TargetCathepsin S(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50401768(CHEMBL2207560)
Affinity DataKi:  1.5nMAssay Description:Inhibition of recombinant Cathepsin S (unknown origin) expressed in Escherichia coli using Z-Val-Val-Arg-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCathepsin S(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50401768(CHEMBL2207560)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50401768(CHEMBL2207560)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin S-mediated antigen presentation in B/T hybridoma cells assessed as IL-2 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401768(CHEMBL2207560)
Affinity DataIC50: 200nMAssay Description:Inhibition of cathepsin L using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401768(CHEMBL2207560)
Affinity DataKi:  385nMAssay Description:Inhibition of human Cathepsin L using Z-Phe-Arg-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCathepsin B(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50401768(CHEMBL2207560)
Affinity DataKi: >1.20E+4nMAssay Description:Inhibition of human Cathepsin B using Z-Phe-Arg-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed