BDBM50404155 CHEMBL5270046

SMILES FC(F)(F)c1ccc(N\N=C\c2coc3c4cc(oc4ccc3c2=O)-c2ccc(Cl)cc2)cc1

InChI Key InChIKey=LCMWUFLTMJGHMS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50404155   

TargetAcetylcholinesterase(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX2 (unknown origin) using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition by microplate spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCholinesterase(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human BuChE using butyrylthiocholine as substrate preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetBeta-secretase 1(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBeta-secretase 1(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant human BACE-1 expressed in baculovirus using Rh-EVNLDAEFK-Quencher as substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of LOX15 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 2.85E+4nMAssay Description:Inhibition of LOX5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50404155(CHEMBL5270046)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human LOX5 using arachidonic acid preincubated for 10 mins followed by substrate addition by microplate spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed