BDBM50404946 CHEMBL4172542

SMILES c1ccc(cc1)-c1cc(-c2ccccc2)c2ncccc2n1

InChI Key InChIKey=HUWQNUYKNJKTQK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50404946   

TargetDNA topoisomerase 1(Human)
Universidad De Le£N

Curated by ChEMBL
LigandPNGBDBM50404946(CHEMBL4172542)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of human Top1B expressed in Top1B deficient Saccharomyces cerevisiae EKY3 assessed as decrease in relaxation of supercoiled pSK DNA preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Universidad De Le£N

Curated by ChEMBL
LigandPNGBDBM50404946(CHEMBL4172542)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human topoisomerase I using DNA pBR322 as substrate assessed as DNA relaxation incubated for 45 mins by ethidium bromide staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50404946(CHEMBL4172542)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated 10 mins followed by substrate addition and measured after 2 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed