BDBM50405520 CHEMBL1822601

SMILES Fc1cccc(F)c1[C@H]1CC[C@@H](N2CCN(C3CCCCC3)CC2)CC1

InChI Key InChIKey=SYNAAQKVKRSFKL-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50405520   

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405520BDBM50405520(CHEMBL1822601)
Affinity DataKi:  0.630nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Catania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405520BDBM50405520(CHEMBL1822601)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor expressed in rat liver membranes assessed as inhibition constant in presence of (+)-pentazocine by radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Catania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405520BDBM50405520(CHEMBL1822601)
Affinity DataEC50:  7.30E+3nMAssay Description:Inhibition of P-gp transporter (unknown origin) expressed in dog MDCK-MDR1 assessed as inhibition of fluorescent Calcein-AM transport by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed