BDBM50405636 CHEMBL5282715

SMILES C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(-c5[nH]c(=O)c(C)nc5-c5ccccc5)cc4)CC3)c2c1

InChI Key InChIKey=CGWRGCGZPRWFTG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50405636   

TargetRAC-alpha serine/threonine-protein kinase(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405636BDBM50405636(CHEMBL5282715)
Affinity DataIC50: 39nMAssay Description:Inhibition of N-terminal His6-tagged TEV protease fused wild-type AKT1 (2 to 446 residues) (unknown origin) expressed in Sf9 cells by HTRF KinEASE as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405636BDBM50405636(CHEMBL5282715)
Affinity DataIC50: 39nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405636BDBM50405636(CHEMBL5282715)
Affinity DataKi:  59nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405636BDBM50405636(CHEMBL5282715)
Affinity DataKi:  59nMAssay Description:Binding affinity to N-terminal His6-tagged TEV protease fused wild-type AKT1 (2 to 446 residues) (unknown origin) expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405636BDBM50405636(CHEMBL5282715)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of N-terminal His6-tagged TEV protease fused wild-type AKT2 (2 to 447 residues) (unknown origin) expressed in Sf9 cells by HTRF KinEASE as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
TU Dortmund University and Drug Discovery Hub Dortmund (DDHD)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405636BDBM50405636(CHEMBL5282715)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of wild-type AKT3 (unknown origin) by HTRF KinEASE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed