BDBM50406123 CHEMBL5277419

SMILES COc1ccc(cc1)-n1nc(C(=O)N2CCN3CCC2CC3)c2COCCc12

InChI Key InChIKey=IOORBTYTULFDSM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50406123   

TargetCeramide glucosyltransferase(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406123(CHEMBL5277419 | US20250171467, Compound 1)
Affinity DataIC50: 7nMAssay Description:Inhibition of Glucosylceramide synthase (unknown origin) using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetUDP-glucose 6-dehydrogenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50406123(CHEMBL5277419 | US20250171467, Compound 1)
Affinity DataEC50:  8.20nMAssay Description:Using Promega's UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2025
Entry Details
US Patent