BDBM50412985 CHEMBL458220

SMILES Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=OZAJLQLEAWUZSC-UHFFFAOYSA-N

Data  10 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50412985   

Target5-hydroxytryptamine receptor 2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  302nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  457nMAssay Description:Displacement of [3H]5HT from 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  589nMAssay Description:Displacement of [3H]5HT from 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  1.45E+3nMAssay Description:Displacement of [3H]prazosin from adrenergic Alpha-1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  3.39E+3nMAssay Description:Displacement of [3H]LSD from 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  3.55E+3nMAssay Description:Displacement of [125I]iodosulpiride from dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi:  5.13E+3nMAssay Description:Displacement of [125I]iodosulpiride from dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-2 adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataKi: <6.31E+3nMAssay Description:Displacement of [125I]iodocyanopindolol from adrenergic beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMas-related G-protein coupled receptor member X1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412985(CHEMBL458220)
Affinity DataEC50:  126nMAssay Description:Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed