BDBM50418606 CHEMBL1784172

SMILES Cc1c(F)cc(cc1-c1ccc(cn1)C(=O)NCC1CC1)C(=O)NC1CC1

InChI Key InChIKey=ZWQSPUPMQMBACD-UHFFFAOYSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50418606   

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataKi:  7.94nMAssay Description:Inhibition of GST-tagged p38alpha by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataKi:  25.1nMAssay Description:Inhibition of GST-tagged p38beta by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataIC50: 79.4nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataIC50: 126nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human PBMC preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human CYP2C19 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human CYP1A2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418606(CHEMBL1784172)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human CYP2C9 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed