BDBM50419247 CHEMBL1835071::US8470835, 1
SMILES Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1
InChI Key InChIKey=KBPYMFSSFLOJPH-UONOGXRCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50419247
Affinity DataIC50: 40nMpH: 7.4 T: 25°CAssay Description:Recombinant human Syk was express as a His-tagged protein. The activity of Syk was asses using a time-resolved fluorescence resonance entery transfe...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMpH: 8.0 T: 30°CAssay Description:Recombinant human Aurora B (2-344) was expressed as a Flag-6His-Thr-tagged protein. The activity of Aurora B was assessed using a Fluorescence Polar...More data for this Ligand-Target Pair
Affinity DataIC50: >7.90E+3nMpH: 7.5 T: 25°CAssay Description:Recombinant human VEGFR2 (KDR) intracellular domain (including the entire kinase domain) was expressed as a GST-6His-tagged protein. The activity of...More data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of human recombinant Flag-6His-Thr-tagged Aurora B assessed as phosphorylation of 5FAM-PKA-tide substrate after 150 mins by fuorescence po...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells after 2 hrs by Cy3b-Dofetilide-based fluorescence polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair