BDBM50419255 CHEMBL1835064

SMILES Cc1cccc(Nc2nc(N[C@H]3CCCC[C@H]3N)ncc2C(N)=O)c1

InChI Key InChIKey=NZNTWOVDIXCHHS-CABCVRRESA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50419255   

TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419255(CHEMBL1835064)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant Flag-6His-Thr-tagged Aurora B assessed as phosphorylation of 5FAM-PKA-tide substrate after 150 mins by fuorescence po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419255(CHEMBL1835064)
Affinity DataIC50:  316nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVenus kinase receptor 2(Blood fluke)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50419255(CHEMBL1835064)
Affinity DataIC50:  5.69E+3nMAssay Description:Inhibition of Schistosoma mansoni N-terminal His6-tagged full-length VKR2 kinase domain expressed in baculovirus infected Sf9 insect cells assessed a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419255(CHEMBL1835064)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells after 2 hrs by Cy3b-Dofetilide-based fluorescence polarisation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVenus kinase receptor 2(Blood fluke)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50419255(CHEMBL1835064)
Affinity DataKd:  1.96E+3nMAssay Description:Binding affinity to Schistosoma mansoni N-terminal His6-tagged full-length VKR2 kinase domain expressed in baculovirus infected Sf9 insect cells in p...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419255(CHEMBL1835064)
Affinity DataIC50:  79nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed