BDBM50420693 CHEMBL2087077

SMILES OC[C@@H](O)CONC(=O)c1oc2ccncc2c1Nc1ccc(I)cc1F

InChI Key InChIKey=MOKOPMFVODBALH-SNVBAGLBSA-N

Data  1 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50420693   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420693(CHEMBL2087077)Copy SMILESCopy InChI

Affinity DataIC50:  25nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation after 30 mins by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420693(CHEMBL2087077)Copy SMILESCopy InChI

Affinity DataEC50:  6.30nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420693(CHEMBL2087077)Copy SMILESCopy InChI

Affinity DataEC50:  34nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL