BDBM50421690 CHEMBL5276957
SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCCCN1CCN(C)CC1
InChI Key InChIKey=XGRCXXKTIOPAEE-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50421690
TargetDisintegrin and metalloproteinase domain-containing protein 8(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 567nMAssay Description:Inhibition of human recombinant ADAM8 using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and measured fo...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant ADAM17 (unknown origin) using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataIC50: 3.48E+5nMAssay Description:Inhibition of MMP-1 in human Rheumatoid Synovial fibroblasts using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 8(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of ADAM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of CD23 shedding by measuring reduction of soluble CD23 release...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of human recombinant MMP-9 expressed in CHO cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Affinity DataIC50: 2.34E+5nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 2.74E+4nMAssay Description:Inhibition of human recombinant ADAM10 expressed in baculovorus-infected Sf21 cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate p...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of human recombinant MMP-2 expressed in mouse cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzy...More data for this Ligand-Target Pair