BDBM50425037 CHEMBL2312555

SMILES COc1cc(\C=C2/CCCN3[C@H](CCON=C23)c2cc(F)c(F)c(F)c2)ccc1-n1cnc(C)c1

InChI Key InChIKey=DLYCRJBHFXFNNZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50425037   

TargetPresenilin-1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50425037(CHEMBL2312555)
Affinity DataIC50: 39nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50425037(CHEMBL2312555)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50425037(CHEMBL2312555)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50425037(CHEMBL2312555)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed