BDBM50425319 CHEMBL2315860

SMILES OC[C@H]1CC[C@@H](CC1)NC(=O)C1CCN(CC1)c1nc2cc(Cl)ccc2o1

InChI Key InChIKey=DCIAJQYVIKONRS-SAZUREKKSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50425319   

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425319(CHEMBL2315860)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COX2 in human fetal fibroblast assessed as inhibition of IL-1beta-mediated PGE2 production after 50 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425319(CHEMBL2315860)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human mPGES1 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425319(CHEMBL2315860)
Affinity DataIC50:  3.62E+3nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425319(CHEMBL2315860)
Affinity DataIC50: >1.91E+4nMAssay Description:Inhibition of human recombinant mPGES-1 using PGH2 as substrate incubated 20 mins prior to substrate addition measured after 30 secs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed