BindingDB BDBM50425831 CHEMBL2312301

BDBM50425831 CHEMBL2312301

SMILES COc1ccccc1CNc1ncc(C(=O)NCCCN2CCCC2=O)c(NC2CCCC2)n1

InChI Key InChIKey=ZXZLVQGNVOKCAS-UHFFFAOYSA-N

Data 24 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50425831

Serine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase receptor TYRO3(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: 400nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Tyrosine-protein kinase Mer(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: 4.68E+3nMAssay Description:Inhibition of Mer (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase receptor UFO(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: 5.70E+3nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Hepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: 4.51E+3nMAssay Description:Inhibition of HGFR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Proto-oncogene tyrosine-protein kinase Src(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Serine/threonine-protein kinase Sgk1(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of SGK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Protein kinase C zeta type(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of PKCzeta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Serine/threonine-protein kinase pim-2(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

MAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Mitogen-activated protein kinase 1(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Insulin receptor(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Inhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Inhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of IKKbeta (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Glycogen synthase kinase-3 beta(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Epidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Casein kinase I isoform delta(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Serine/threonine-protein kinase Chk2(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase ABL1(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase receptor TYRO3(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: 400nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

P-selectin(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: 1.70E+4nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL

BDBM50425831(CHEMBL2312301)

IC50: >3.00E+4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Filter my 24 hits

Targets 23▿
- Tyrosine-protein kinase receptor TYRO3 2
- Mitogen-activated protein kinase 1 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Casein kinase I isoform delta 1
- Tyrosine-protein kinase ABL1 1
- Tyrosine-protein kinase receptor UFO 1
- Tyrosine-protein kinase Mer 1
- Serine/threonine-protein kinase pim-2 1
- Epidermal growth factor receptor 1
- RAC-alpha serine/threonine-protein kinase 1
- Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Serine/threonine-protein kinase Chk2 1
- Protein kinase C zeta type 1
- Serine/threonine-protein kinase Chk1 1
- MAP kinase-activated protein kinase 2 1
- Hepatocyte growth factor receptor 1
- Serine/threonine-protein kinase Sgk1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 1
- Insulin receptor 1
- P-selectin 1
- Glycogen synthase kinase-3 beta 1
Publications 2▿
- Bioorg Med Chem Lett 23: 1046-50 (2013) 22
- Bioorg Med Chem Lett 23: 1051-5 (2013) 2
Institutions 1▿
- Pfizer 24
Affinity: 4.0E+2 to 3.0E+4 nM▿
- IC50 24
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0