BDBM50427361 CHEMBL2325727::US10654855, Example 11A::US11236095, Example 11B::US9492453, 11A

SMILES CN(C)CC[C@H](NC(=O)C1(N)CCN(CC1)c1ncnc2[nH]ccc12)c1ccc(Cl)cc1

InChI Key InChIKey=VZOXJFOAJQVTTK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50427361   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM50427361(CHEMBL2325727 | US9492453, 11A | US10654855, Examp...)
Affinity DataIC50: 2.80nMpH: 7.5 T: 2°CAssay Description:This assay detects inhibitors of AKT1 (PKBα) kinase activity using Caliper LabChip LC3000. The Caliper off-chip incubation mobility shift assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2017
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM50427361(CHEMBL2325727 | US9492453, 11A | US10654855, Examp...)
Affinity DataIC50: 2.80nMAssay Description:For Echo dosing the solvent was 100% DMSO. A master plate was prepared with 40 ul of 10 mM stock from our Primary Liquid Store in quadrant 1 of a Lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM50427361(CHEMBL2325727 | US9492453, 11A | US10654855, Examp...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant Akt1 (unknown origin) using 5-FAM-labeled peptide as substrate after 1 hr by caliper off-chip incubation mobility shift ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM50427361(CHEMBL2325727 | US9492453, 11A | US10654855, Examp...)
Affinity DataIC50: 21nMAssay Description:Following addition of compound or control to the assay plate, 6p1 peptide mix containing 3 μM substrate (5-FAM-GRPRTSSFAEG-CONH2; CRB) and 40 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50427361(CHEMBL2325727 | US9492453, 11A | US10654855, Examp...)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant ROCK2 (unknown origin) using 5-FAM-labeled peptide as substrate after 1 hr by caliper off-chip incubation mobility shift as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50427361(CHEMBL2325727 | US9492453, 11A | US10654855, Examp...)
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by ionworks assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed