BDBM50429613 CHEMBL2334590

SMILES Cc1nc2ccc(Cl)cn2c1-c1ccnc(N)n1

InChI Key InChIKey=HLCLCIHQZZSHDC-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50429613   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amgen

Curated by ChEMBL

LigandBDBM50429613(CHEMBL2334590)Copy SMILESCopy InChI

Affinity DataIC50: 600nMAssay Description:Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Janssen Pharmaceutica

Curated by ChEMBL

LigandBDBM50429613(CHEMBL2334590)Copy SMILESCopy InChI

Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of human full length recombinant His-tagged PIK3CD/PIK3R1 expressed in baculovirus expression system after 60 mins by LanthaScreen Eu bind...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/15/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amgen

Curated by ChEMBL

LigandBDBM50429613(CHEMBL2334590)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of NIK in human HT-29 cells assessed as LTalpha/beta2-induced p100 processing to NFkappaB2 preincubated for 30 mins before LTalpha/beta2 s...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL