BDBM50430156 CHEMBL2338695

SMILES Oc1c(Cl)cccc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=MIFXBNFNNPOWOG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50430156   

TargetTransmembrane protease serine 4(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50430156(CHEMBL2338695)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant TMPRSS4 (unknown origin) fused with enterokinase cleavage sequence DYKDDDGDYKDDDDK expressed in Esch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50430156(CHEMBL2338695)
Affinity DataIC50:  58nMAssay Description:Antagonist activity at non-desensitizing human P2X1 receptor ( P2X2/P2X1 chimera) expressed in human 1321N1 cells assessed as inhibition of ATP-induc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 7(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50430156(CHEMBL2338695)
Affinity DataIC50:  177nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 3(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50430156(CHEMBL2338695)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50430156(CHEMBL2338695)
Affinity DataIC50:  49nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 2(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50430156(CHEMBL2338695)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed