BDBM50430602 CHEMBL2338743

SMILES CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45

InChI Key

Data  4 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50430602   

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50430602(CHEMBL2338743)
Affinity DataKi:  0.0510nMAssay Description:Displacement of [3H]-diprenorphine from human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50430602(CHEMBL2338743)
Affinity DataEC50:  0.0830nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50430602(CHEMBL2338743)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]-diprenorphine from rat recombinant MOR expressed in rat C6 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50430602(CHEMBL2338743)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]U69593 from KOR in Hartley guinea pig membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50430602(CHEMBL2338743)
Affinity DataIC50: 0.520nMAssay Description:Agonist activity at kappa opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50430602(CHEMBL2338743)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]DAMGO from MOR in Hartley guinea pig membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50430602(CHEMBL2338743)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at rat recombinant MOR expressed in rat C6 cells assessed as stimulation of [35S]GTPgammaS binding after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed