BDBM50431220 CHEMBL2332610

SMILES C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSCc3cc(CSC[C@H](NC(=O)[C@@H](N)CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N4CCC[C@H]4C(=O)N2)cc(CSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@@H](CCCCN)C(O)=O)c3

InChI Key InChIKey=JRYGECRIWPBGKA-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50431220   

TargetCoagulation factor XII(Human)
Ecole Polytechnique F�D�Rale De Lausanne Epfl

Curated by ChEMBL
LigandPNGBDBM50431220(CHEMBL2332610)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human biotinylated beta factor 12a expressed in Escherichia coli TG1 using Z-Gly-Gly-Arg-AMC as substrate assessed as residual activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlasminogen(Human)
Ecole Polytechnique F�D�Rale De Lausanne Epfl

Curated by ChEMBL
LigandPNGBDBM50431220(CHEMBL2332610)
Affinity DataKi:  8.30E+3nMAssay Description:Inhibition of human plasmin using H-D-Val-Leu-Lys-AMC as substrate assessed as residual activity by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Ecole Polytechnique F�D�Rale De Lausanne Epfl

Curated by ChEMBL
LigandPNGBDBM50431220(CHEMBL2332610)
Affinity DataKi: >1.20E+5nMAssay Description:Inhibition of human trypsin using Z-Gly-Gly-Arg-AMC as substrate assessed as residual activity by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Ecole Polytechnique F�D�Rale De Lausanne Epfl

Curated by ChEMBL
LigandPNGBDBM50431220(CHEMBL2332610)
Affinity DataKi: >1.20E+5nMAssay Description:Inhibition of human PK using Z-Phe-Arg-AMC as substrate assessed as residual activity by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProthrombin(Human)
Ecole Polytechnique F�D�Rale De Lausanne Epfl

Curated by ChEMBL
LigandPNGBDBM50431220(CHEMBL2332610)
Affinity DataKi: >1.20E+5nMAssay Description:Inhibition of human thrombin using Z-Gly-Gly-Arg-AMC as substrate assessed as residual activity by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Ecole Polytechnique F�D�Rale De Lausanne Epfl

Curated by ChEMBL
LigandPNGBDBM50431220(CHEMBL2332610)
Affinity DataKi: >1.20E+5nMAssay Description:Inhibition of human tPA using Z-Gly-Gly-Arg-AMC as substrate assessed as residual activity by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Ecole Polytechnique F�D�Rale De Lausanne Epfl

Curated by ChEMBL
LigandPNGBDBM50431220(CHEMBL2332610)
Affinity DataKi: >1.20E+5nMAssay Description:Inhibition of human uPA using Z-Gly-Gly-Arg-AMC as substrate assessed as residual activity by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Ecole Polytechnique F�D�Rale De Lausanne Epfl

Curated by ChEMBL
LigandPNGBDBM50431220(CHEMBL2332610)
Affinity DataKi: >1.20E+5nMAssay Description:Inhibition of human coagulation factor 11a using Boc-Phe-Ser-Arg-AMC as substrate assessed as residual activity by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed