BDBM50433314 CHEMBL1337960::[14C]-Tacrine Monohydrate Monohydrochloride

SMILES Nc2c1CCCCc1nc3ccccc23

InChI Key InChIKey=YLJREFDVOIBQDA-UHFFFAOYSA-N

Data  9 IC50  1 Kd

PDB links: 7 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50433314   

TargetAcetylcholinesterase(Electric eel)
University of New South Wales

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 10nMAssay Description:Inhibition of electric eel AChE using ATCh as substrate preincubated for 1 hr followed by substrate addition by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCholinesterase(Horse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 20nMAssay Description:Inhibition of equine serum BChE using BTC as substrate incubated for 2 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human BChE using BTC as substrate incubated for 2 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Horse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 30nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Horse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataKd:  49nMAssay Description:Binding affinity to equine BChE in phosphate buffer at pH 8 assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Electric eel)
University of New South Wales

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 54nMAssay Description:Inhibition of electric eel AChE using ATC as substrate incubated for 2 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 73nMAssay Description:Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Electric eel)
University of New South Wales

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433314BDBM50433314([14C]-Tacrine Monohydrate Monohydrochloride | CHEM...)
Affinity DataIC50: 290nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed