BDBM50433536 CHEMBL2381373

SMILES CC(C)n1ncnc1-c1nc-2c(CCOc3cc(ccc-23)-c2cnn(CCO)c2)s1

InChI Key InChIKey=YZIQNVDBRMRXLM-UHFFFAOYSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50433536   

LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataKi:  0.270nMAssay Description:Inhibition of GST-fused human recombinant PI3Kalpha expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataKi:  0.550nMAssay Description:Inhibition of GST-fused human recombinant PI3Kgamma expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataKi:  0.610nMAssay Description:Inhibition of GST-fused human recombinant PI3Kdelta expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataKi:  15nMAssay Description:Inhibition of GST-fused human recombinant PI3Kbeta expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataIC50: >4.30E+3nMAssay Description:Inhibition of mTOR (unknown origin) assessed as inhibition of GFP-4E-BP1 phosphorylation after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of GST-fused human recombinant PI3Kbeta expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3Kalpha in human MCF7-neo/Her2 cells assessed as reduction of AKT phosphorylation at S473More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin) assessed as 3,4,5-inositoltriphosphate formation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50433536(CHEMBL2381373)
Affinity DataIC50:  24nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells assessed as inhibition of AKT phosphorylation at Ser473 after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed