BDBM50434821 CHEMBL2387224

SMILES c1cc(c(c(c1)Cl)C(=O)Nc2ccnc(c2)NC(=O)C3CC3)Cl

InChI Key InChIKey=IAFNAEGXTKTGHN-UHFFFAOYSA-N

Data  9 KI  4 IC50  4 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50434821   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataKi:  28nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataKi:  28nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataKi:  28nMAssay Description:Inhibition of JAK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataKi:  84nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataKi:  84nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataKi:  111nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataKi:  253nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataKi:  253nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434821BDBM50434821(CHEMBL2387224)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed