BDBM50436643 3-(5-(1-(2-(Benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)-benzoic acid (Compound 1b)::CHEMBL2398292
SMILES CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1cccc(c1)C(O)=O
InChI Key InChIKey=VXBRZBNJAKCQTI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50436643
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataKd: 850nMpH: 2.2 T: 2°CAssay Description:A concentration series of each compound was injected at a flow rate of 90 µL/min over three spots at 25°C. The times allowed for compound a...More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assayMore data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 2.20E+3nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 9.00E+3nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as direct binding constant at steady state by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 2(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Walter and Eliza Hall Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 1.20E+4nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl by surface plasmon resonance assayMore data for this Ligand-Target Pair