BDBM50437837 CHEMBL2407897

SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(\C=C4\C(=O)Nc5ccccc45)ccc23)cc1

InChI Key InChIKey=HCLJFCCORISDCX-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50437837   

TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 4nMAssay Description:Inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 4nMAssay Description:Inhibition of human N-terminal GST-tagged PLK4 (1 to 391 residues) expressed in Escherichia coli incubated for 30 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 22nMAssay Description:Inhibition of KDR (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 35nMAssay Description:Inhibition of FLT3 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 940nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BFC substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin) using MFC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin) using MFC substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using MFC as substrate after 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using MFC substrate after 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin) using AMMC substrate after 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin) using AMMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) using CEC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK2 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) using CEC substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50437837(CHEMBL2407897)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK3 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed