BDBM50438639 CHEMBL2414437::US9732037, Compound 5
SMILES Cc1cc(N)nc(COc2cncc(CNCCc3cccc(F)c3)c2)c1
InChI Key InChIKey=IGLNPZZNPBQOMM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50438639
Affinity DataKi: 140nMAssay Description:Inhibition of recombinant rat nNOS expressed in Escherichia coli using L-arginine as substrate assessed as formation of nitric oxide measured up to 6...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 140nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
Affinity DataKi: 2.86E+3nMAssay Description:Inhibition of recombinant mouse macrophage iNOS expressed in Escherichia coli using L-arginine as substrate assessed as formation of nitric oxide mea...More data for this Ligand-Target Pair
Affinity DataKi: 2.86E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
Affinity DataKi: 7.11E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
Affinity DataKi: 1.04E+4nMAssay Description:Inhibition of recombinant bovine eNOS expressed in Escherichia coli using L-arginine as substrate assessed as formation of nitric oxide measured up t...More data for this Ligand-Target Pair
TargetNitric oxide synthase oxygenase(Bacillus subtilis (strain 168))
University of California Irvine
University of California Irvine
Affinity DataKd: 2.37E+5nMAssay Description:In short, the difference between the imidazole-bound low-spin peak at 430 nm and the inhibitorbound high-spin peak at 395 nm was measured as a functi...More data for this Ligand-Target Pair