BDBM50439628 CHEMBL2419609::US8993586, 2

SMILES CC(C)n1ncc2CC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)NC(=O)c12

InChI Key InChIKey=UYUARKZGQUFSSK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50439628   

TargetAcetyl-CoA carboxylase 1(Human)
Pfizer

US Patent
LigandPNGBDBM50439628(CHEMBL2419609 | US8993586, 2)
Affinity DataIC50:  24.2nMpH: 7.5Assay Description:Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetAcetyl-CoA carboxylase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50439628(CHEMBL2419609 | US8993586, 2)
Affinity DataIC50:  55nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Human)
Pfizer

US Patent
LigandPNGBDBM50439628(CHEMBL2419609 | US8993586, 2)
Affinity DataIC50:  86nMAssay Description:Inhibition of human ACC1 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50439628(CHEMBL2419609 | US8993586, 2)
Affinity DataIC50:  19nMAssay Description:Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...More data for this Ligand-Target Pair
In DepthDetails US Patent