BDBM50439677 CHEMBL2417790::US9169209, Table 3, Compound 55

SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1ccccc1)\C=C\c1cccnc1

InChI Key InChIKey=RIGDHZDQFISNAD-MDWZMJQESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50439677   

TargetNicotinamide phosphoribosyltransferase(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50439677(CHEMBL2417790 | US9169209, Table 3, Compound 55)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant his-tagged NAMPT (unknown origin) expressed in Escherichia coli after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNicotinamide phosphoribosyltransferase(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50439677(CHEMBL2417790 | US9169209, Table 3, Compound 55)
Affinity DataIC50:  4nMpH: 7.5 T: 25°CAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In DepthDetails US Patent