BDBM50441090 CHEMBL2430323::US9669028, 114 N-(3-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenyl)acetamide

SMILES CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1

InChI Key InChIKey=YFBPGSDPFRCNOY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50441090   

TargetSerine/threonine-protein kinase Chk1(Human)
University of Edinburgh Cancer Research Centre In The Institute of Genetics and Molecular Medicine

Curated by ChEMBL
LigandPNGBDBM50441090(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Affinity DataIC50: 233nMAssay Description:Inhibition of human CHK1 in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 15(Human)
University of Edinburgh Cancer Research Centre In The Institute of Genetics and Molecular Medicine

Curated by ChEMBL
LigandPNGBDBM50441090(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human ERK8 in presence of 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Rat)
University of Edinburgh Cancer Research Centre In The Institute of Genetics and Molecular Medicine

Curated by ChEMBL
LigandPNGBDBM50441090(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Affinity DataIC50: 894nMAssay Description:Inhibition of rat CK1delta in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM50441090(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM50441090(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase Nek2(Human)
University of Edinburgh Cancer Research Centre In The Institute of Genetics and Molecular Medicine

Curated by ChEMBL
LigandPNGBDBM50441090(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human NEK2alpha in presence of 50 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed