BDBM50441212 CHEMBL2431028
SMILES NC(=O)NCCC[C@@H](NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1)C(=O)NO
InChI Key InChIKey=QTXVPJOTKLUYMQ-QGZVFWFLSA-N
Data 17 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50441212
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 845nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of ADAM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of CD23 shedding by measuring reduction of soluble CD23 release...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 651nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 1 hr measured every 15 secs for...More data for this Ligand-Target Pair
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant ADAM8 using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and measured fo...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant ADAM17 (unknown origin) using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of MMP-1 in human Rheumatoid Synovial fibroblasts using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant MMP-2 expressed in mouse cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzy...More data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of human recombinant MMP-9 expressed in CHO cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3 hrs followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant ADAM10 expressed in baculovorus-infected Sf21 cells using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate p...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
UniversitÀ
Curated by ChEMBL
UniversitÀ
Curated by ChEMBL
Affinity DataIC50: 4.27E+3nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min...More data for this Ligand-Target Pair