BDBM50441213 CHEMBL2431027

SMILES ONC(=O)[C@@H](CCCNC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1

InChI Key InChIKey=HJLAUHYNMNIAAR-XMMPIXPASA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50441213   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  500nMAssay Description:Inhibition of ADAM-17 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  3.70E+5nMAssay Description:Inhibition of human MMP-1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of recombinant human MMP-2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of recombinant human MMP-9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition of recombinant human MMP-14 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  500nMAssay Description:Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  100nMAssay Description:Inhibition of ADAM-17 in human L428 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  349nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  5.64E+3nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  350nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  7.63E+3nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  274nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 1 hr measured every 15 secs for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
San Raffaele Scientific Institute

Curated by ChEMBL
LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  500nMAssay Description:Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed