BDBM50441710 CHEMBL2435866

SMILES CC(CCNC(=O)c1c(C)cc(Cl)nc1C)N1CCC(CC1)N1[C@@H](CN(Cc2ccc(cc2)C(O)=O)C1=O)c1ccccc1

InChI Key InChIKey=KDKOAYRCXAQUFY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50441710   

TargetC-C chemokine receptor type 5(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50441710(CHEMBL2435866)
Affinity DataIC50: 1nMAssay Description:Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50441710(CHEMBL2435866)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50441710(CHEMBL2435866)
Affinity DataIC50: 42nMAssay Description:Displacement of [125I]-RANTES from CCR5 (unknown origin) expressed in HEK293F cell membranes after 45 mins by microbeta jet liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed