BDBM504425 N-(5-((4-((1-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3- dioxoisoindolin-5- yl)oxy)ethyl)piperazin-4- yl)methyl)piperzin-1- yl)methyl)-1-((1s,4s)-4- (hydroxymethyl)cyclohexyl)- 1H-benzo[d]imidazol-2-yl)- 3- (trifluoromethyl)benzamide::US11065231, Example 10

SMILES OC[C@H]1CCC(CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CC4CCN(CCOc5ccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c6c5)CC4)CC3)ccc12

InChI Key InChIKey=ADRHLDYNIIKAIY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504425   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Arvinas Operations

US Patent
LigandPNGBDBM504425(N-(5-((4-((1-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3...)
Affinity DataIC50: 30nMAssay Description:A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent