BDBM50443230 CHEMBL3086885

SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)c(Cl)c1O

InChI Key InChIKey=NPQKWPKFRWMJFA-UHFFFAOYSA-N

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50443230   

TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataKi:  170nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataKi:  170nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataKi:  240nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataKi:  320nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataKi:  640nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNucleosome-remodeling factor subunit BPTF(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of fluorescein-labeled MS239 from recombinant human BPTF after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain adjacent to zinc finger domain protein 2B(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataKi:  3.30E+3nMAssay Description:Displacement of fluorescein-labeled MS239 from recombinant human BAZ2b after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Mouse)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated nitric oxide production preincubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Mouse)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated IL-6 expression preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443230BDBM50443230(CHEMBL3086885)
Affinity DataKi:  5.59E+3nMAssay Description:Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed