BDBM50443504 CHEMBL3087783

SMILES Cc1nn(C)cc1-c1nc2ncc(Cl)c(Nc3ccc(cc3)C(=O)Nc3ccccc3)c2[nH]1

InChI Key InChIKey=KRQUQAQHMVDXTH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443504   

TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50443504(CHEMBL3087783)
Affinity DataIC50: 75nMAssay Description:Inhibition of N-terminal HIS-tagged aurora-A (unknown origin) using 5FAM-LRRASLG-CONH2 as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50443504(CHEMBL3087783)
Affinity DataIC50: 320nMAssay Description:Inhibition of autophosphorylation of N-terminal Myc tagged aurora-A at T288 (unknown origin) after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50443504(CHEMBL3087783)
Affinity DataIC50: 4.12E+3nMAssay Description:Inhibition of full-length aurora-B (unknown origin) using 5FAMLRRASLG-CONH2 as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50443504(CHEMBL3087783)
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of N-terminal Myc tagged aurora-B (unknown origin)-mediated histone H3 phosphorylation at S10 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed