BDBM50446286 CHEMBL3109232

SMILES CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(OC(C)C)cc4)ccc3c2)cc1

InChI Key InChIKey=GIZAAIBWOAGCID-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50446286   

TargetNuclear receptor ROR-gamma(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50446286(CHEMBL3109232)
Affinity DataIC50: 6nMAssay Description:Inverse agonist activity at biotinylated human RORgammat LBD expressed in Escherichia coli BL21 assessed as inhibition of SRC1 recruitment after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50446286(CHEMBL3109232)
Affinity DataIC50: 70nMAssay Description:Inverse agonist activity at RORgammat in mouse Th17 cells assessed as effect on cell differentiation measured as IL-17 level after 3 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed