BDBM504463 N-(1-((1s,4s)-4-((2-(2-((2- (2,6-dioxopiperidin-3-yl)- 1,3-dioxoisoindolin-5- yl)oxy)ethoxy)ethoxy)methyl) cyclohexyl)-5-(piperidin-1- ylmethyl)-1H- benzo[d]imidazol-2-yl)-3- (trifluoromethyl)benzamide::US11065231, Example 44

SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nc2cc(CN3CCCCC3)ccc2n1[C@@H]1CC[C@H](COCCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1

InChI Key InChIKey=IGETVZNUIVLPFH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504463   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Arvinas Operations

US Patent
LigandPNGBDBM504463(N-(1-((1s,4s)-4-((2-(2-((2- (2,6-dioxopiperidin-3-...)
Affinity DataIC50: 1.00E+3nMAssay Description:A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent