BDBM50448378 CHEMBL3121474

SMILES C[N+](C)(CCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2ccccc2C1=O

InChI Key InChIKey=YAIIIRVTWFRIIK-UHFFFAOYSA-N

Data  6 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50448378   

TargetMuscarinic acetylcholine receptor M2(Pig)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50448378(CHEMBL3121474)
Affinity DataEC50:  66nMAssay Description:Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50448378(CHEMBL3121474)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50448378(CHEMBL3121474)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50448378(CHEMBL3121474)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50448378(CHEMBL3121474)
Affinity DataKi:  204nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50448378(CHEMBL3121474)
Affinity DataKi:  275nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Pig)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50448378(CHEMBL3121474)
Affinity DataEC50:  871nMAssay Description:Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50448378(CHEMBL3121474)
Affinity DataKi:  3.02E+4nMAssay Description:Displacement of [3H]-NMS from wild-type human muscarinic M5 receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed