BDBM504486 N-(2-(1-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3- dioxoisoindolin-4- yl)amino)ethoxy)ethoxy)ethyl) piperadin-4-yl)-6-methoxy- 2H-indazol-5-yl)-6- (trifluoromethyl)picolinamide::US11065231, Example 62

SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCOCCOCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)CC1

InChI Key InChIKey=KNVLGMLXFFVJLW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504486   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Arvinas Operations

US Patent
LigandPNGBDBM504486(N-(2-(1-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,...)
Affinity DataIC50: 30nMAssay Description:A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent