BDBM50448969 CHEMBL3125517::US9296736, 256::US9593129, Example 256

SMILES CN(C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)S(=O)(=O)C1CC1

InChI Key InChIKey=GNBHDBPUJCJXQG-GCMXZSHTSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50448969   

LigandPNGBDBM50448969(CHEMBL3125517 | US9296736, 256 | US9593129, Exampl...)
Affinity DataIC50: <10nMpH: 7.4 T: 25°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM50448969(CHEMBL3125517 | US9296736, 256 | US9593129, Exampl...)
Affinity DataIC50: <1nMpH: 7.4 T: 25°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
International Institute For Translational Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50448969(CHEMBL3125517 | US9296736, 256 | US9593129, Exampl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p53-MDM2 interaction (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM50448969(CHEMBL3125517 | US9296736, 256 | US9593129, Exampl...)
Affinity DataIC50: <10nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM50448969(CHEMBL3125517 | US9296736, 256 | US9593129, Exampl...)
Affinity DataIC50: <1nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
International Institute For Translational Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50448969(CHEMBL3125517 | US9296736, 256 | US9593129, Exampl...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed