BDBM50450058 CHEMBL4159806

SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nnc(Cc4ccc(F)cc4F)cc23)[C@@H](CN2Cc3ccc(cc3C2=O)C#N)CN1

InChI Key InChIKey=GGSBCIHJHQMJEB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50450058   

TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450058(CHEMBL4159806)
Affinity DataIC50: 1.60nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450058(CHEMBL4159806)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed