BDBM50450703 CHEMBL4159086::US11028041, Compound 30

SMILES COC(=O)c1c(cc(c(c1CCc2ccccc2Cc3ccc(cc3)F)Cl)O)O

InChI Key InChIKey=IJGOZBLFBZMVDS-UHFFFAOYSA-N

Data  2 IC50  4 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50450703   

TargetEndoplasmin(Dog)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataIC50: 540nMAssay Description:Inhibition of FITC-geldanamycin binding to canine GRP94 incubated for 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndoplasmin(Dog)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataKd:  540nMAssay Description:The assay was performed in 96-well black, flat-bottom plates with a final volume of 100 μL. 25 μL of assay buffer (20 mM HEPES, pH 7.3, 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetEndoplasmin(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant GRP94 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataKd:  540nMAssay Description:Binding affinity to Hsp90alpha (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataKd:  3.92E+4nMAssay Description:The assay was performed in 96-well black, flat-bottom plates with a final volume of 100 μL. 25 μL of assay buffer (20 mM HEPES, pH 7.3, 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetEndoplasmin(Dog)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataKd:  3.92E+4nMAssay Description:Binding affinity to dog GRP94 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataIC50: 3.92E+4nMAssay Description:Inhibition of FITC-geldanamycin binding to HSP90alpha (unknown origin) incubated for 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataIC50: 3.92E+4nMAssay Description:Inhibition of HSP90alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed