BDBM50450959 CHEMBL4210698::US11795171, Compound I-56

SMILES C[C@H](CC(=O)N1CCC(O)(Cn2cnn3cccc3c2=O)CC1)c1ccccc1

InChI Key InChIKey=BXIGMHDBRKSFSG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50450959   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Valo Health

US Patent
LigandPNGBDBM50450959(CHEMBL4210698 | US11795171, Compound I-56)
Affinity DataIC50: 50nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Valo Health

US Patent
LigandPNGBDBM50450959(CHEMBL4210698 | US11795171, Compound I-56)
Affinity DataIC50: 200nMAssay Description:Inhibition of human USP7 using ubiquitin-Rh110 as substrate incubated for 23 to 45 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Valo Health

US Patent
LigandPNGBDBM50450959(CHEMBL4210698 | US11795171, Compound I-56)
Affinity DataIC50: 200nMAssay Description:Inhibition of His6-tagged USP7 (208 to 1102 residues) (unknown origin) using ubiquitin-rhodamine110 as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed